IDR - Immune Diagnostics & Research

Case Reports

A case report and review of the literature: Ciprofloxacin resistant Salmonella enterica serovar Typhi in India

Belgode Narasimha Harish, Godfred Antony Menezes, Kengamuthu Sarangapani, Subhash Chandra Parija

Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry



Background: Enteric fever is a major public health problem in India. The current treatment of choice is the fluoroquinolones.
Methods: The minimum inhibitory concentration (MIC) of ciprofloxacin was determined by E-test, HIMEDIA HiComb MIC test and agar dilution.
Results: An isolate of Salmonella enterica serovar Typhi (S. Typhi) from a case of enteric fever gave a ciprofloxacin MIC of 64μg/ml.
Conclusions: To our knowledge there have been no reports of such high-level resistance to ciprofloxacin in S. Typhi from southern India. HIMEDIA HiComb MIC test method is an alternative to the E-test. Ciprofloxacin resistant typhoid fever responds to treatment with ceftriaxone.


Enteric fever, Salmonella Typhi, drug resistance

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