TY - JOUR AU - Abdo, Anselmo AU - Alfonso, Carlos AU - Diaz, Guillermo AU - Wilford, Mario AU - Rocha, Maykel AU - Verdecia, Niurka PY - 2010/07/19 Y2 - 2024/03/28 TI - Fatal 2009 pandemic influenza A (H1N1) in a bone marrow transplant recipient JF - The Journal of Infection in Developing Countries JA - J Infect Dev Ctries VL - 5 IS - 02 SE - Case Reports DO - 10.3855/jidc.1066 UR - https://www.jidc.org/index.php/journal/article/view/21389594 SP - 132-137 AB - <p>Conditions characterized by immunosuppression have been recently reported as risk factors for severe novel swine-origin influenza A (H1N1) virus (S-OIV) infection during the current 2009 pandemic.  We report clinical and virological findings, antiviral therapy, and post-mortem study of S-OIV in an adult bone marrow transplant recipient. The viral genome was amplified by real time reverse transcriptase polymerase chain reaction (RT-PCR) from a nasopharyngeal swab specimen. The patient developed acute respiratory distress syndrome, septic shock, and eventually succumbed with a severe pulmonary haemorrhage. To the best of our knowledge, the entire clinical/therapy management and pathological examination in a transplant recipient infected with the S-OIV has not been previously documented. The fatal ending in this bone marrow transplant recipient supports recommendations that call for education measures, S-OIV vaccination, early diagnosis and aggressive treatment in the transplant population.</p> ER -