TY - JOUR AU - Le, Nhan Trong AU - Donadu, Matthew Gavino AU - Ho, Duc Viet AU - Doan, Tuan Quoc AU - Le, Anh Tuan AU - Raal, Ain AU - Usai, Donatella AU - Sanna, Giuseppina AU - Marchetti, Mauro AU - Usai, Marianna AU - Diaz, Nicia AU - Rapelli, Paola AU - Zanetti, Stefania AU - Cappuccinelli, Piero AU - Nguyen, Hoai Thi PY - 2020/09/30 Y2 - 2024/03/28 TI - Biological activities of essential oil extracted from leaves of Atalantia sessiflora Guillauminin Vietnam JF - The Journal of Infection in Developing Countries JA - J Infect Dev Ctries VL - 14 IS - 09 SE - Original Articles DO - 10.3855/jidc.12469 UR - https://www.jidc.org/index.php/journal/article/view/33031096 SP - 1054-1064 AB - <p>Introduction: The present study aimed to determine the chemical compositions and bioactivities of the essential oil of <em>Atalantia sessiflora</em> Guillaumin (<em>A. sessiflora</em>), including antibacterial, antimycotic, antitrichomonas, anti-inflammatory and antiviral effects.</p><p>Methodology: The essential oil from leaves of <em>A. sessiflora</em> was extracted by hydrodistillation using a Clevenger apparatus. Chemical compositions of oil were identified by GC/MS. Antimicrobial and antitrichomonas activity were determined by the microdilution method; anti-inflammatory and antiviral were determined by the MTT method.</p><p>Results: The average yield of oil was 0.46 ± 0.01% (v/w, dry leaves). A number of 45 constituents were identified by GC/MS. The essential oil comprised four main components. The oil showed antimicrobial activities against Gram-positive strains as <em>Staphylococcus</em>; Gram-negative bacteria such as <em>Klebsiella pneumoniae</em> and <em>Escherichia coli</em>; and finally four <em>Candida</em> species. <em>Enterococcus faecalis</em> and <em>Pseudomonas aeruginosa</em> were least susceptible to the oil of <em>A. sessiflora</em>, as seen in their MIC and MLC values over 16% (v/v). Activity against <em>Trichomonas vaginalis </em>was also undertaken, showing IC<sub>50</sub>, IC<sub>90</sub> and MLC values of 0.016, 0.03 and 0.06% (v/v) respectively, after 48 hours of incubation. The oil of <em>A. sessiflora</em> displayed activity against the nitric oxide generation with the IC<sub>50</sub> of 95.94 ± 6.18 µg/mL. The oil was completely ineffective against tested viruses, ssRNA+, ssRNA-, dsRNA, and dsDNA viruses.</p><p>Conclusions: This is the first yet comprehensive scientific report about the chemical compositions and pharmacological properties of the essential oil of <em>A. sessiflora</em>. Further studies should be done to evaluate the safety and toxicity of <em>A. sessiflora</em> oil.</p> ER -