Multidrug-Resistant and Extensively Drug Resistant Tuberculosis in Kashmir, India

Authors

  • Bikram Singh Datta Government Medical College associated Chest Diseases Hospital, Srinagar, Kashmir
  • Ghulam Hassan Department of Medicine, Government Medical College associated SMHS Hospital, Srinagar, Kashmir
  • Syed Manzoor Kadri Regional Institute of Health and FW, DHS, Srinagar, Kashmir
  • Waseem Qureshi Government Medical College associated SMHS Hospital, Srinagar, Kashmir
  • Mustadiq Ahmad Kamili Department of Medicine, Government Medical College associated SMHS Hospital, Srinagar, Kashmir
  • Hardeep Singh Department of Medicine, Government Medical College associated SMHS Hospital, Srinagar, Kashmir
  • Ahmad Manzoor Department of Medicine, Government Medical College associated SMHS Hospital, Srinagar, Kashmir
  • Mushtaq Ahmad Wani Department of Medicine, Government Medical College associated SMHS Hospital, Srinagar, Kashmir
  • Shamas u Din Department of Chest Medicine, Government Medical College and associated Chest Diseases Hospital, Srinagar, Kashmir
  • Natasha Thakur Department of Surgery , Sheri Kashmir Institute of Medical Sciences , Kashmir

DOI:

https://doi.org/10.3855/jidc.669

Keywords:

tuberculosis, multidrug-resistant tuberculosis, extensively drug resistant tuberculosis, drug susceptibility testing

Abstract

Background: To study the profile of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) in tertiary care hospital setting, representing almost the whole affected population in Kashmir valley of India.

Methodology: A total of 910 cases of pulmonary tuberculosis were enrolled over four years. Among these, cases of MDR-TB and XDR-TB were meticulously studied for drug susceptibility, treatment, adverse effects profile and overall survival.

Results: Fifty-two (5.7%) cases of MDR-TB were identified, among which eight (15.3%) were diagnosed as XDR-TB on the basis of drug susceptibility testing, using the prescribed definition. The cases were sensitive to 2, 3, 4, 5 and more than 5 drugs in almost equal proportions. Thirty-seven (71.1%) cases were successfully cured; eleven (21.1%) patients died; and only four (7.6%) cases defaulted, indicating overall satisfactory adherence to treatment.

Conclusion: For effective treatment of MDR-TB and XDR-TB, early case detection, improved laboratory facilities, availability of appropriate treatment regimens, and financial assistance in resource-limited settings through effective political intervention are necessary for better patient adherence and overall cure.

Author Biographies

Bikram Singh Datta, Government Medical College associated Chest Diseases Hospital, Srinagar, Kashmir

Government Medical College associated Chest Diseases Hospital, Srinagar, Kashmir, India

Ghulam Hassan, Department of Medicine, Government Medical College associated SMHS Hospital, Srinagar, Kashmir

 

  Department of Medicine, Government Medical College associated SMHS Hospital, Srinagar, Kashmir, India

Syed Manzoor Kadri, Regional Institute of Health and FW, DHS, Srinagar, Kashmir

Regional Institute of Health and FW, DHS, Srinagar, Kashmir, India,

Waseem Qureshi, Government Medical College associated SMHS Hospital, Srinagar, Kashmir

Government Medical College associated SMHS Hospital, Srinagar, Kashmir, India

Mustadiq Ahmad Kamili, Department of Medicine, Government Medical College associated SMHS Hospital, Srinagar, Kashmir

Department of Medicine, Government Medical College associated SMHS Hospital, Srinagar, Kashmir, India

Hardeep Singh, Department of Medicine, Government Medical College associated SMHS Hospital, Srinagar, Kashmir

Department of Medicine, Government Medical College associated SMHS Hospital, Srinagar, Kashmir, India

Ahmad Manzoor, Department of Medicine, Government Medical College associated SMHS Hospital, Srinagar, Kashmir

Department of Medicine, Government Medical College associated SMHS Hospital, Srinagar, Kashmir, India

Mushtaq Ahmad Wani, Department of Medicine, Government Medical College associated SMHS Hospital, Srinagar, Kashmir

Department of Medicine, Government Medical College associated SMHS Hospital, Srinagar, Kashmir, India

Shamas u Din, Department of Chest Medicine, Government Medical College and associated Chest Diseases Hospital, Srinagar, Kashmir

Department of Chest Medicine, Government Medical College and associated Chest Diseases Hospital, Srinagar, Kashmir, India

Natasha Thakur, Department of Surgery , Sheri Kashmir Institute of Medical Sciences , Kashmir

Department of Surgery , Sheri Kashmir Institute of Medical Sciences , Kashmir,India
January 2010 cover

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Published

2009-11-21

How to Cite

1.
Datta BS, Hassan G, Kadri SM, Qureshi W, Kamili MA, Singh H, Manzoor A, Wani MA, Din S u, Thakur N (2009) Multidrug-Resistant and Extensively Drug Resistant Tuberculosis in Kashmir, India. J Infect Dev Ctries 4:019–023. doi: 10.3855/jidc.669

Issue

Vol. 4 No. 01: January 2010

Section

Original Articles

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