In vitro antimicrobials activity against endemic Acinetobacter baumannii multiresistant clones

Authors

  • Carlos Hernan Rodriguez Laboratorio de Bacteriología, Departamento de Bioquímica Clínica, Hospital de Clínicas José de San Martín, Facultad de Farmacia y Bioquímica. Universidad de Buenos Aires. Buenos Aires, Argentina.
  • Alejandra De Ambrosio Carrera de Especialistas Bacteriología Clínica Facultad de Farmacia y Bioquímica. Universidad de Buenos Aires. Buenos Aires, Argentina.
  • Milena Bajuk Carrera de Especialistas Bacteriología Clínica Facultad de Farmacia y Bioquímica. Universidad de Buenos Aires. Buenos Aires, Argentina.
  • Mariela Spinozzi Carrera de Especialistas Bacteriología Clínica Facultad de Farmacia y Bioquímica. Universidad de Buenos Aires. Buenos Aires, Argentina.
  • Marcela Nastro Laboratorio de Bacteriología, Departamento de Bioquímica Clínica, Hospital de Clínicas José de San Martín, Facultad de Farmacia y Bioquímica. Universidad de Buenos Aires. Buenos Aires, Argentina.
  • Karina Bombicino Laboratorio de Bacteriología, Departamento de Bioquímica Clínica, Hospital de Clínicas José de San Martín, Facultad de Farmacia y Bioquímica. Universidad de Buenos Aires. Buenos Aires, Argentina.
  • Marcela Radice Cátedra de Microbiología Facultad de Farmacia y Bioquímica. Universidad de Buenos Aires. Buenos Aires, Argentina.
  • Gabriel Gutkind Cátedra de Microbiología Facultad de Farmacia y Bioquímica. Universidad de Buenos Aires. Buenos Aires, Argentina.
  • Carlos Vay Laboratorio de Bacteriología, Departamento de Bioquímica Clínica, Hospital de Clínicas José de San Martín, Facultad de Farmacia y Bioquímica. Universidad de Buenos Aires. Buenos Aires, Argentina.
  • Angela Famiglietti Laboratorio de Bacteriología, Departamento de Bioquímica Clínica, Hospital de Clínicas José de San Martín, Facultad de Farmacia y Bioquímica. Universidad de Buenos Aires. Buenos Aires, Argentina.

DOI:

https://doi.org/10.3855/jidc.604

Keywords:

A. baumannii, Time-kill assay, Colistin-Heteroresistance, Rifampicin, Imipenem

Abstract

Background: Multidrug-resistant strains of Acinetobacter baumannii have been reported increasingly around the world. The administration of an association of antibiotics has been proposed to create an active combination and to prevent the emergence of resistance.

Methodology: The activity of colistin, rifampicin, gentamicin, imipenem and their associations was evaluated by means of killing curves in fourteen isolates belonging to three endemic PFGE types, in a university hospital of Buenos Aires city. The 14 isolates were selected on the basis of different mechanisms responsible for resistance to carbapenems and different susceptibility to colistin.

Results: The mechanism responsible for the resistance to imipenem was the production of OXA-23 and OXA-58 carbapenemases. Heteroresistance to colistin was observed in six isolates. The associations colistin-rifampicin and colistin-imipenem were synergistic in heteroresistant isolates and prevented the development of colistin-resistant mutants. The association imipenem-gentamicin was bactericidal in gentamicin susceptible isolates, whereas the association imipenem-rifampicin was always indifferent.

Conclusion: The antimicrobial activity and the presence of synergy are related to the antimicrobials' susceptibilities irrespective of the PFGE type or the OXA-carbapenemase produced.

Author Biography

Carlos Hernan Rodriguez, Laboratorio de Bacteriología, Departamento de Bioquímica Clínica, Hospital de Clínicas José de San Martín, Facultad de Farmacia y Bioquímica. Universidad de Buenos Aires. Buenos Aires, Argentina.

camana 2604 6piso6 Depto12 (1417) Buenos Aires Argentina

Downloads

Published

2010-02-03

How to Cite

1.
Rodriguez CH, De Ambrosio A, Bajuk M, Spinozzi M, Nastro M, Bombicino K, Radice M, Gutkind G, Vay C, Famiglietti A (2010) In vitro antimicrobials activity against endemic Acinetobacter baumannii multiresistant clones. J Infect Dev Ctries 4:164–167. doi: 10.3855/jidc.604

Issue

Section

Brief Original Articles