Serotypes and antibiotic susceptibility of Streptococcus pneumoniae isolates causative of invasive diseases in Mexican children

  • José Luis Arredondo-García Instituto Nacional de Pediatría, Mexico City, Mexico
  • Ernesto Calderón Hospital Infantil de México Federico Gómez, Mexico City, Mexico
  • Gabriela Echániz-Aviles Instituto Nacional de Salud Pública, Cuernavaca, Mor., Mexico
  • Araceli Soto-Noguerón Instituto Nacional de Salud Pública, Cuernavaca, Mor., Mexico
  • Patricia Arzate Instituto Nacional de Pediatría, Mexico City, Mexico
  • Carlos F Amabile-Cuevas Fundación Lusara, Mexico City, Mexico
Keywords: Streptoccocus penumoniae, pediatric invasive disease, serotypes, antibiotic resistance

Abstract

Introduction: Streptococcus pneumoniae is a worldwide leading cause of morbidity and mortality, while susceptibility towards penicillin and

macrolides can be less than 50% in many regions.

Methodology: A total of 150 isolates of S. pneumoniae causative of invasive diseases in children were characterized, of which 24.6% had a fatal outcome.

Results: The most prevalent serotypes were 19F, 6B, 23F and 14. Resistance to penicillin, erythromycin (mostly of macrolide-lincosamide-streptogramin resistance phenotype) or trimethoprim-sulfamethoxazole was found in more than 40% of the isolates, but no resistance phenotype appeared linked to lethality. Serotype 3 isolates, which were seldom resistant, had a twofold lethality rate compared to the total sample.

Conclusion: Serotyping could provide a better outcome-predicting tool than susceptibility testing. The seven-valent vaccine does not include the most prevalent serotypes found in Mexico.

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Author Biography

Carlos F Amabile-Cuevas, Fundación Lusara, Mexico City, Mexico
Head, Department of Microbiology, Fundacion Lusara, Mexico City
Published
2010-10-20
How to Cite
1.
Arredondo-GarcíaJL, Calderón E, Echániz-AvilesG, Soto-NoguerónA, Arzate P, Amabile-CuevasCF (2010) Serotypes and antibiotic susceptibility of Streptococcus pneumoniae isolates causative of invasive diseases in Mexican children. J Infect Dev Ctries 5:119-122. doi: 10.3855/jidc.1348
Section
Brief Original Articles