Cytomegalovirus infection in non-immunosuppressed critically ill patients

  • Manisha Jain Department of Microbiology, G. B. Pant Hospital, Delhi, India
  • Shalini Duggal Department of Microbiology, B. L. Kapur Memorial Hospital, Delhi, India
  • Tulsi Das Chugh Department of Microbiology, B. L. Kapur Memorial Hospital, Delhi, India
Keywords: CMV, reactivation, critically ill, ICU patients

Abstract

Cytomegalovirus (CMV) is an important and common cause of mortality and morbidity in immunocompromised patients such as those with HIV/AIDS, transplant recipients on immunosuppressive therapy, and malignant hematological disease. After primary infection with CMV the virus becomes latent in multiple organs and can later be reactivated during severe dysregulation of the immune system. A large population carry dormant virus and are thus at risk for reactivation.

However, reactivation of CMV has been reported in "non-immunosuppressed patients" such as severe trauma, sepsis, shock, burns, cirrhosis and other critically ill patients lying in the intensive care units. Therefore, the intensivists are increasingly facing a dilemma of identifying such patients to treat and there is a debate if there is a scientific justification for prophylaxis in such immunocompetent patients.

Author Biographies

Manisha Jain, Department of Microbiology, G. B. Pant Hospital, Delhi, India

Assistant Professor

Department of Microbiology

Shalini Duggal, Department of Microbiology, B. L. Kapur Memorial Hospital, Delhi, India

Consultant,

Department of Microbiology

Tulsi Das Chugh, Department of Microbiology, B. L. Kapur Memorial Hospital, Delhi, India

Senior Consultant

Dep[artment of Microbiology

Published
2011-03-30
How to Cite
1.
Jain M, Duggal S, Chugh TD (2011) Cytomegalovirus infection in non-immunosuppressed critically ill patients. J Infect Dev Ctries 5:571-579. doi: 10.3855/jidc.1487
Section
Reviews