The MCP-1 (CCL2) -2518 GG genotype is associated with protection against pulmonary tuberculosis in Moroccan patients

Naima Arji; Marc Busson; Ghali Iraqi; Jamal Eddine Bourkadi; Abdelaziz Benjouad; Wahid Boukouaci; Ouafae Lahlou; Jouda Ben Amor; Rajagopal Krishnamoorthy; Dominique Charron; Rajae El Aouad; Ryad Tamouza

doi:10.3855/jidc.1925

The MCP-1 (CCL2) -2518 GG genotype is associated with protection against pulmonary tuberculosis in Moroccan patients

Authors

Naima Arji National Institute of Hygiene, Agdal, Rabat, Morocco
Marc Busson CIB-HOG, AP-HP, IUH and INSERM, UMRS, 940, Saint-Louis Hospital, Paris, France
Ghali Iraqi Moulay Youssef Hospital, Ibn Sina University, Rabat, Morocco
Jamal Eddine Bourkadi Moulay Youssef Hospital, Ibn Sina University, Rabat, Morocco
Abdelaziz Benjouad Faculty of Sciences, Mohamed V University, Rabat, Morocco
Wahid Boukouaci CIB-HOG, AP-HP, IUH and INSERM, UMRS, 940, Saint-Louis Hospital, Paris, France
Ouafae Lahlou Bacteriology Department, National Institute of Hygiene, Agdal, Rabat, Morocco
Jouda Ben Amor Pneumology Department, Moulay Youssef Hospital, Ibn Sina University, Rabat, Morocco
Rajagopal Krishnamoorthy INSERM, U763, Robert Debré Hospital, Paris, France
Dominique Charron CIB-HOG, AP-HP, IUH and INSERM, UMRS, 940, Saint-Louis Hospital, Paris, France
Rajae El Aouad National Institute of Hygiene, Agdal, Rabat, Morocco
Ryad Tamouza CIB-HOG, AP-HP, IUH and INSERM, UMRS, 940, Saint-Louis Hospital, Paris, France

DOI:

https://doi.org/10.3855/jidc.1925

Keywords:

Pulmonary tuberculosis, Monocyte chemoattractant protein-1, Interleukin-12 p40, polymorphism, Morocco.

Abstract

Introduction: Both monocyte chemoattractant protein-1 (MCP-1), also designated officially as chemokine (C-C motif) ligand 2 (CCL2), and interleukin-12 p40 (IL-12 p40) molecules, encoded by polymorphic genes, are central components of the immune response to infection by Mycobacterium tuberculosis (Mtb). Their genetic diversity has previously been associated with the outcome of tuberculosis (TB) infection. We investigated whether the MCP-1 -2518 A/G and the IL-12B (p40) +1188 A/C polymorphisms influence susceptibility to or resistance against pulmonary tuberculosis (PTB) in a Moroccan population group.
Methodology: Genomic DNA from 337 patients along with 204 healthy controls were genotyped for the above-mentioned genetic variations using polymerase chain reaction-based restriction fragment length polymorphism assay.
Results: We found a higher prevalence of homozygous MCP-1 -2518 G allele in healthy individuals than in patients (pc = 0.04; odds ratio = 0.35; 95% confidence interval = 0.13 - 0.86), suggesting a potential protective effect, whereas analysis of IL-12B +1188 variation failed to reveal any such association.
Conclusion: Our results are in agreement with recent findings in Ghanaian patients, complying with the known genetic admixture of the Moroccan population.

Author Biography

Ryad Tamouza, CIB-HOG, AP-HP, IUH and INSERM, UMRS, 940, Saint-Louis Hospital, Paris, France

Associate Professor in Immunology and Immunogenetics

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Published

2011-09-26

How to Cite

Arji N, Busson M, Iraqi G, Bourkadi JE, Benjouad A, Boukouaci W, Lahlou O, Ben Amor J, Krishnamoorthy R, Charron D, El Aouad R, Tamouza R (2011) The MCP-1 (CCL2) -2518 GG genotype is associated with protection against pulmonary tuberculosis in Moroccan patients. J Infect Dev Ctries 6:73–78. doi: 10.3855/jidc.1925

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Issue

Vol. 6 No. 01: January 2012

Section

Original Articles

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