Immune response to influenza A(H1N1)v in HIV-infected patients

Paola Sansonetti; Michela Sali; Massimiliano Fabbiani; Matteo Morandi; Rosa Martucci; Ali Danesh; Giovanni Delogu; Jesus Bermejo-Martin; Maurizio Sanguinetti; David Kelvin; Roberto Cauda; Giovanni Fadda; Salvatore Rubino

doi:10.3855/jidc.3147

Immune response to influenza A(H1N1)v in HIV-infected patients

Authors

Paola Sansonetti Catholic University of Sacred Heart, Rome, Italy
Michela Sali Catholic University of Sacred Heart, Rome, Italy
Massimiliano Fabbiani Catholic University of Sacred Heart, Rome, Italy
Matteo Morandi Catholic University of Sacred Heart, Rome, Italy
Rosa Martucci Catholic University of Sacred Heart, Rome, Italy
Ali Danesh International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China
Giovanni Delogu Catholic University of Sacred Heart, Rome, Italy
Jesus Bermejo-Martin Infection and Immunity Medical Investigation Unit (IMI), Microbiology and Immunology Service, Hospital Clínico Universitario-IECSCYL, Valladolid, Spain
Maurizio Sanguinetti Catholic University of Sacred Heart, Rome, Italy
David Kelvin International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China
Roberto Cauda Catholic University of Sacred Heart, Rome, Italy
Giovanni Fadda Catholic University of Sacred Heart, Rome, Italy
Salvatore Rubino University of Sassari, Sassari, Italy

DOI:

https://doi.org/10.3855/jidc.3147

Keywords:

HIV, influenza A(H1N1)v 2009, cytokines, chemokines, antibody response

Abstract

Introduction: HIV infection is considered a risk factor for severe outcomes of influenza A(H1N1)v infection. However, data on immune response against influenza A(H1N1)v virus in HIV-infected patients are lacking.

Methodology: Data from seven HIV-positive and 14 HIV-negative patients infected with A(H1N1)v and from 23 HIV-positive and six HIV-negative asymptomatic controls were analyzed to evaluate the clinical picture, A(H1N1)v viral shedding, and the immune response against the virus.

Results: Patients displayed mainly upper respiratory tract diseases (57.1%), while pneumonia was diagnosed only in HIV-negative patients (23.8% of subjects, of which 4.8% required intensive care unit admission). At day seven, 29% of HIV-infected patients were still positive for A(H1N1)v by RT-PCR on nasopharyngeal swabs. Interestingly, a persistence of CXCL10 secretion at high level and lower IL-6 levels was observed in HIV-positive subjects. The geometric mean haemagglutination inhibition titer (HI-GMT) and anti-influenza IgM levels were lower in HIV-positive individuals while anti-influenza IgG levels remained similar in the two groups.

Conclusions: The immune impairment due to HIV infection could affect A(H1N1)v clearance and could lead to a lower antibody response and a persistent secretion of CXCL10 at high levels. However, the lower IL-6 secretion and treatment with highly active antiretroviral therapy (HAART) could result in a milder clinical picture.

Author Biography

Michela Sali, Catholic University of Sacred Heart, Rome, Italy

Institute of Microbiology

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Published

2014-01-15

How to Cite

Sansonetti P, Sali M, Fabbiani M, Morandi M, Martucci R, Danesh A, Delogu G, Bermejo-Martin J, Sanguinetti M, Kelvin D, Cauda R, Fadda G, Rubino S (2014) Immune response to influenza A(H1N1)v in HIV-infected patients. J Infect Dev Ctries 8:101–109. doi: 10.3855/jidc.3147

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Issue

Vol. 8 No. 01: January 2014

Section

Original Articles

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