Bleeding complications in dengue are not associated with significant changes in the modulators of the endothelial barrier

  • Fernanda Andrade Orsi Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil
  • Rodrigo Nogueira Angerami Epidemiological Surveillance Center, Hospital of Clinics, University of Campinas, Campinas, Brazil
  • Bruna Moraes Mazetto Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil
  • Susan Kelly Picoli Quaino Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil
  • Erich Vinícius de Paula Faculty of Medical Sciences, University of Campinas, Campinas, Brazil
  • Joyce Maria Annichino-Bizzachi Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil
Keywords: dengue, bleeding tendency, VEGF

Abstract

Bleeding complications in dengue may occur irrespective of the presence of plasma leakage. We compared plasma levels of modulators of the endothelial barrier among three dengue groups: bleedings without plasma leakage, dengue hemorrhagic fever, and non-complicated dengue. The aim was to evaluate whether the presence of subtle alterations in microvascular permeability could be detected in bleeding patients. Plasma levels of VEGF-A and its soluble receptors were not associated with the occurrence of bleeding in patients without plasma leakage. These results provide additional rationale for considering bleeding as a complication independent of endothelial barrier breakdown, as proposed by the 2009 WHO classification.

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Author Biographies

Fernanda Andrade Orsi, Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil

Head of the Laboratory of Hemostasis of the Hematology and Hemotherapy Center - University of Campinas, Campinas, Brasil

Rodrigo Nogueira Angerami, Epidemiological Surveillance Center, Hospital of Clinics, University of Campinas, Campinas, Brazil
Assistent Physician at Epidemiological Surveillance Center of the Hospital of Clinicas of the University of Campinas, Campinas, Brasil.
Bruna Moraes Mazetto, Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil

PhD student at  Hematology and Hemoterapy Center, University of Campinas, Campinas, Brasil

Susan Kelly Picoli Quaino, Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil
PhD student at Hematology and Hemotherapy Center, University of Campinas, Campinas, Brasil
Erich Vinícius de Paula, Faculty of Medical Sciences, University of Campinas, Campinas, Brazil

Professor in Hematology of the Department of Clinical Pathology, Faculty of Medical Sciences of the University of Campinas

Joyce Maria Annichino-Bizzachi, Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil
Professor in Hematology and Hemotherapy of the Hematology and Hemotherapy Canter of the University of Campinas, Campinas, Brasil
Published
2014-06-11
How to Cite
1.
Orsi FA, Angerami RN, Mazetto BM, Quaino SKP, de PaulaEV, Annichino-BizzachiJM (2014) Bleeding complications in dengue are not associated with significant changes in the modulators of the endothelial barrier. J Infect Dev Ctries 8:799-803. doi: 10.3855/jidc.4542
Section
Short Communications