Increasing frequency of Pseudomonas aeruginosa infections during tigecycline use

  • Aysegul Ulu-Kilic Faculty of Medicine, Erciyes University, Kayseri, Turkey
  • Emine Alp Faculty of Medicine, Erciyes University, Kayseri, Turkey
  • Dilek Altun Erciyes University, Faculty of Medicine, Kayseri, Turkey
  • Fatma Cevahir Erciyes University, Faculty of Medicine, Kayseri, Turkey
  • Gamze Kalın Faculty of Medicine, Erciyes University, Kayseri, Turkey
  • Hayati Demiraslan Faculty of Medicine, Erciyes University, Kayseri, Turkey
Keywords: Pseudomonas aeruginosa, tigecycline, infection

Abstract

Introduction: The widespread use of tigecycline raises the question of increasing infection rates of Pseudomonas aeruginosa (PA) in ICUs which are not affected by this antibiotic.

Objective:  The aim of this study was to determine if treatment with tigecycline is a risk factor for PA infection in ICU patients.

Methodology: A retrospective and observational study was conducted at Erciyes University Hospital, Turkey, between 2008 and 2010. The Erciyes University Hospital is a 1300-bed tertiary care facility. The patients included in this study were hospitalized in four adult ICUs. Patients with PA infections (case group) were compared with patients with nosocomial infection other than PA (control group).

Results: A total of 1,167 patients with any nosocomial infections were included in the study. Two hundred and seventy eight (23.8%) of the patients had PA infection during their ICU stay. Fifty nine patients (21.2%) in the case group received tigecycline before developing PA infections, which were found to be significantly more frequent than in the controls (p < 0.01). Multivariate analysis showed that risk factors for PA infection were previous tigecycline use (4 times), external ventricular shunt (4.2 times), thoracic drainage catheter (2.5 times) and tracheostomy (1.6 times).

Conclusion: Our results contribute to the need for new studies to determine the safety of tigecycline use, especially for the treatment of critically ill patients. Since tigecycline seems to be an alternative for the treatment of multidrug resistant (MDR) microorganisms, rational use of this antibiotic in ICU patients is essential.

Author Biographies

Aysegul Ulu-Kilic, Faculty of Medicine, Erciyes University, Kayseri, Turkey
Infectious Disease and Clinical Microbiology
Emine Alp, Faculty of Medicine, Erciyes University, Kayseri, Turkey

Infectious Disease and Clinical Microbiology

Dilek Altun, Erciyes University, Faculty of Medicine, Kayseri, Turkey
Infection Control Committee
Fatma Cevahir, Erciyes University, Faculty of Medicine, Kayseri, Turkey
Infection Control Committee
Gamze Kalın, Faculty of Medicine, Erciyes University, Kayseri, Turkey

Infectious Disease and Clinical Microbiology

Hayati Demiraslan, Faculty of Medicine, Erciyes University, Kayseri, Turkey

Infectious Disease and Clinical Microbiology

Published
2015-03-15
How to Cite
1.
Ulu-Kilic A, Alp E, Altun D, Cevahir F, Kalın G, Demiraslan H (2015) Increasing frequency of Pseudomonas aeruginosa infections during tigecycline use. J Infect Dev Ctries 9:309-312. doi: 10.3855/jidc.4700
Section
Brief Original Articles