IL-28B genotypes as predictors of long-term outcome in patients with hepatitis C-related severe liver injury

Authors

  • Jelena Jordovic Clinic for Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, Serbia
  • Jasmina Simonovic-Babic Clinic for Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, Serbia
  • Vladimir Gasic Laboratory for Molecular Biomedicine, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia
  • Nikola Kotur Laboratory for Molecular Biomedicine, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade
  • Branka Zukic Laboratory for Molecular Biomedicine, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade
  • Sonja Pavlovic Medical Faculty, University of Belgrade, Belgrade, Serbia
  • Ivana Lazarevic Institute of Microbiology and Immunology, Belgrade, Serbia
  • Danijela Karalic Institute of Microbiology and Immunology, Belgrade, Serbia
  • Natasa Katanic Clinic for Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, Serbia
  • Natasa Nikolic Clinic for Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, Serbia
  • Aleksandar Urosevic Clinic for Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, Serbia
  • Jelena Nestorov Medical Faculty, University of Belgrade, Belgrade, Serbia
  • Dragan Delic Clinic for Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, Serbia
  • Ksenija Bojovic Clinic for Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, Serbia

DOI:

https://doi.org/10.3855/jidc.11351

Keywords:

interleukine 28B, late relapse, outcome

Abstract

Introduction: Patients with severe fibrosis or cirrhosis are at high risk for liver-related complications, even after successful antiviral treatment and/or regression of fibrosis. These are the first published results concerning the role of IL-28B genotypes as predictors of the durability of sustained virological response (SVR) and long-term outcome, in patients with baseline severe fibrosis and cirrhosis caused by hepatitis C (HCV) infection.

Methodology: Genetic testing for three different single nucleotide polymorphisms (SNP) near the IL28B gene, rs12979860, rs12980275 and rs8099917, was performed in 42 patients with HCV-related advanced fibrosis and cirrhosis, who achieved SVR after successful interferon-based treatment. Baseline clinical and laboratory parameters were analysed, as well as IL28B genotype association with late virological relapse, fibrosis progression and clinical outcomes.

Results: The most prevalent genotypes in all three tested SNP positions were: CCrs12979860 genotype in 69% of patients, GTrs8099917 in 78.6% and GGrs12980275 in 47.6% of patients. The presence of IL28B CCrs12979860 genotype was identified as a negative predictor of late virological relapse. Further analysis did not confirm the association of other IL28B genotypes with the progression of fibrosis and clinical outcomes.

Conclusions: Varying long-term prognosis in patients with HCV-related severe fibrosis and cirrhosis is due to multiple interactions between host genetic factors, virus and environment. These are first published results demonstrating the significance of IL28B CCrs12979860 genotype as a negative predictor of late virological relapse. A further investigation concerning genetic factors is necessary to identify patients under risk for late relapse, complications and unfavorable outcomes, so that they can be reevaluated and offered new treatment options.

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Published

2019-05-31

How to Cite

1.
Jordovic J, Simonovic-Babic J, Gasic V, Kotur N, Zukic B, Pavlovic S, Lazarevic I, Karalic D, Katanic N, Nikolic N, Urosevic A, Nestorov J, Delic D, Bojovic K (2019) IL-28B genotypes as predictors of long-term outcome in patients with hepatitis C-related severe liver injury. J Infect Dev Ctries 13:526–535. doi: 10.3855/jidc.11351

Issue

Vol. 13 No. 06: June 2019

Section

Original Articles

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