Assessment and outcome of hospitalized patients during delta variant COVID-19 pandemic: A multicenter international study

Authors

  • Fatma Abdelaziz Amer Department of Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
  • Maysaa Abdallah Saeed Viral Infection Working Group of International Society of Antimicrobial Chemotherapy VIWG/ISAC https://orcid.org/0000-0001-8045-2864
  • Shaker Wagih Shaltout Department of Tropical Medicine, Port Said University, Port Said, Egypt https://orcid.org/0000-0002-4304-3276
  • Hanaa Abu Elazayem Nofal Department of Public Health and Preventive Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt https://orcid.org/0000-0002-5909-4238
  • Ramadan Mahmoud Nafae Department of Pulmonary Medicine, Zagazig Faculty of Medicine, Zagazig, Egypt
  • Kadem Arslan Department of Internal Medicine, Sancaktepe Sehit Prof Dr Ilhan Varank Training and Research Hospital, Istanbul, Turkey https://orcid.org/0000-0002-3957-3821
  • Alpaslan Tanoglu Viral Infection Working Group of International Society of Antimicrobial Chemotherapy VIWG/ISAC https://orcid.org/0000-0002-7477-6640
  • Mihai Nechifor Viral Infection Working Group of International Society of Antimicrobial Chemotherapy VIWG/ISAC https://orcid.org/0000-0002-3667-8783
  • Catalina Luca Viral Infection Working Group of International Society of Antimicrobial Chemotherapy VIWG/ISAC https://orcid.org/0000-0003-4694-9177
  • Zaid Hashim Ali Al-kadhim MBChB. A.B.M. Kazemia Education Hospital, Baghdad, Iraq https://orcid.org/0000-0003-3102-4921
  • Ahmed Mosallem Department of Anesthesia and Surgical Intensive Care, Faculty of Medicine, Zagazig University, Zagazig, Egypt https://orcid.org/0000-0002-4363-800X
  • Noha Mohammed Hammad Department of Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt https://orcid.org/0000-0002-9400-7822

DOI:

https://doi.org/10.3855/jidc.16696

Keywords:

COVID-19 pandemic, outcome predictors, SARS-COV-2

Abstract

Introduction: To date, the world has experienced four waves of the Coronavirus disease- 19 (COVID-19) pandemic. Patients infected during the era of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant were the subject of this study. The objectives were to describe their clinical manifestations, explain their laboratory and radiological findings, conclude factors contributing to clinical outcomes, and evaluate treatment protocols.

Methodology: Relevant data were collected retrospectively from records of patients admitted to six referral centers in four countries. Data included sociodemographic patterns, symptoms, associated comorbidities, physical examination, laboratory and radiologic findings, treatment received, and patient outcomes.

Results: Data analysis identified symptomatology and variables related to acquisition and infection outcome. The most prevalent symptoms were cough (81.5%), body aches (74.1%), and fever (71.6%). Independent risk factors for mortality were age, vomiting, epigastric pain, diabetes, obesity, oxygen saturation less than 90%, leukocytosis, neutrophilia, lymphopenia, thrombocytopenia, elevated creatinine, high glucose level, lung ground glass opacities with consolidation, affection of four lobes and bilateralism. Neither d-dimer nor lactate dehydrogenase nor ferritin foretells death possibility. The efficacy of the medications used was convenient.

Conclusions: Assessing the clinical features of different COVID-19 waves, identifying predictors of outcomes, and concluding the efficacy of treatment protocols provide insight into patients’ responses and viral behaviors, which help in the proper diagnosis and treatment of subsequent surges.

Downloads

Download data is not yet available.

Downloads

Published

2022-11-29

How to Cite

1.
Amer FA, Saeed MA, Wagih Shaltout S, Nofal HAE, Nafae RM, Arslan K, Tanoglu A, Nechifor M, Luca C, Al-kadhim ZHA, Mosallem A, Hammad NM (2022) Assessment and outcome of hospitalized patients during delta variant COVID-19 pandemic: A multicenter international study. J Infect Dev Ctries 16:1715–1725. doi: 10.3855/jidc.16696

Issue

Section

Coronavirus Pandemic