Can Bacillus paranthracis cause bacteremia in a T-ALL patient? WGS-based diagnosis

Serap Süzük Yıldız; Ayşegül Polat; Süleyman Yalçın; Mert Emre Ölmez; Tahir Darçın; Kerem Özdel; İpek Mumcuoğlu; Tuba Dal

doi:10.3855/jidc.20080

Can Bacillus paranthracis cause bacteremia in a T-ALL patient? WGS-based diagnosis

Authors

Serap Süzük Yıldız Department of Clinical Microbiology, University of Health Sciences, Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkey https://orcid.org/0000-0002-4820-6986
Ayşegül Polat Department of Clinical Microbiology, University of Health Sciences, Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkey
Süleyman Yalçın Department of Microbiology Reference Laboratories, General Directorate of Public Health, Ministry of Health, Ankara, Turkey
Mert Emre Ölmez Department of Clinical Microbiology, University of Health Sciences, Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkey https://orcid.org/0009-0005-2377-4185
Tahir Darçın Department of Hematology Clinic and Bone Marrow Transplantation, University of Health Sciences, Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkey https://orcid.org/0000-0001-5073-1790
Kerem Özdel Massive Bioinformatics, Ankara, Turkey https://orcid.org/0000-0001-9601-6979
İpek Mumcuoğlu Department of Clinical Microbiology, University of Health Sciences, Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkey
Tuba Dal Department of Clinical Microbiology, University of Health Sciences, Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkey https://orcid.org/0000-0001-7045-1462

DOI:

https://doi.org/10.3855/jidc.20080

Keywords:

Bacillus paranthracis, bacteremia, hematologic malignancy, whole genome sequencing

Abstract

Introduction: Most of Bacillus spp. generally avirulent species in healthy patients, but if there is a fragile in the patient, especially their immune system, Bacillus spp. can be an agent for infections.

Case Report: In this case, we report that Bacillus paranthracis, diagnosed by whole genome sequencing, is responsible for bacteremia in a T-ALL patient. A 26-year-old male patient was diagnosed with T-cell acute lymphoblastic leukemia. Bacillus paranthracis was isolated from two sets of blood cultures obtained from a patient with febrile neutropenia.

Results: The bacteria was identified as Bacillus cereus group in a routine microbiology laboratory by MALDI TOF MS. Then whole genome sequencing (WGS) confirmed its name as Bacillus paranthracis. The pathogenicity of the bacterium, especially in immunocompromised patients, has also been demonstrated by WGS.

Conclusions: In a microbiology laboratory, the use of Whole Genome Sequencing (WGS) is important for diagnosing diseases, especially in immunocompromised patients. It will serve the management of these patients for infection control.

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Published

2025-03-31

How to Cite

Süzük Yıldız S, Polat A, Yalçın S, Ölmez ME, Darçın T, Özdel K, Mumcuoğlu İpek, Dal T (2025) Can Bacillus paranthracis cause bacteremia in a T-ALL patient? WGS-based diagnosis. J Infect Dev Ctries 19:458–461. doi: 10.3855/jidc.20080

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Issue

Vol. 19 No. 03: March 2025

Section

Case Reports

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