Antibiotic stewardship program (ASP) implementation is more effective than the national action plan for rational drug use

Cem Karaali; Huseyin Esin; Orhan Ureyen; Ozan Barıs Namdaroglu; Murat Can Kale; Mustafa Emiroglu; Savas Yakan; Enver Ilhan; Mehmet Burak Oztop; Sukran Kose

doi:10.3855/jidc.20245

Antibiotic stewardship program (ASP) implementation is more effective than the national action plan for rational drug use

Authors

Cem Karaali Department of General Surgery, University of Health Sciences Izmir Faculty of Medicine, Tepecik Education and Research Hospital, Yenisehir, Izmir, Turkey https://orcid.org/0000-0003-2743-7360
Huseyin Esin Department of General Surgery, University of Health Sciences Izmir Faculty of Medicine, Tepecik Education and Research Hospital, Yenisehir, Izmir, Turkey
Orhan Ureyen Department of General Surgery, University of Health Sciences Izmir Faculty of Medicine, Bozyaka Education and Research Hospital, Karabaglar, Izmir, Turkey
Ozan Barıs Namdaroglu Department of General Surgery, University of Health Sciences Izmir Faculty of Medicine, Tepecik Education and Research Hospital, Yenisehir, Izmir, Turkey
Murat Can Kale Department of General Surgery, University of Health Sciences Izmir Faculty of Medicine, Bozyaka Education and Research Hospital, Karabaglar, Izmir, Turkey https://orcid.org/0000-0002-9667-4602
Mustafa Emiroglu Department of General Surgery, University of Health Sciences Izmir Faculty of Medicine, Tepecik Education and Research Hospital, Yenisehir, Izmir, Turkey
Savas Yakan Department of General Surgery, University of Health Sciences Izmir Faculty of Medicine, Bozyaka Education and Research Hospital, Karabaglar, Izmir, Turkey
Enver Ilhan Department of General Surgery, University of Health Sciences Izmir Faculty of Medicine, Bozyaka Education and Research Hospital, Karabaglar, Izmir, Turkey
Mehmet Burak Oztop Directorate General for Health Improvement, Izmir Provincial Health Directorate, Konak, Izmir, Turkey
Sukran Kose Department of Infectious Diseases, Dokuz Eylul University Research and Application Hospital, Balcova, Izmir, Turkey

DOI:

https://doi.org/10.3855/jidc.20245

Keywords:

Antimicrobial stewardship, surveillance, long-term results

Abstract

Introduction: In this study, we investigated the long-term effects of different antibiotic stewardship programs on surgical prophylaxis (SP) and the continuation of SP at discharge prescription in two general surgery clinics.

Methods: We retrospectively examined SP practices in the general surgery clinics of two hospitals. In Clinic A, a modified antibiotic stewardship program (mASP) was implemented, while in Clinic B, practices were conducted within the scope of the National Action Plan for Rational Drug Use (NAPRDU). A cross-sectional comparison was made by including quarterly data from both clinics for the years 2013, 2016, 2018, and 2023.

Results: When the SP practices in clinics A and B were analyzed in detail according to year, we found that SP indication, SP use for > 24 hours, antibiotic use in prescription, and all stages of SP (prescription and non-prescription) improved for both clinics except for the time of SP administration (p < 0.05). Moreover, a significantly greater and faster improvement in these parameters was found in clinic A than in clinic B.

Conclusions: Our study showed that the mASP and the NAPRDU have positive long-term effects on SP practices in general surgery clinics and the implementation of SP in discharge prescriptions. However, in clinics where mASP was applied, SP practices generally improved faster and more effectively, especially in terms of the antibiotics prescribed in discharge.

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Published

2025-06-30

How to Cite

Karaali C, Esin H, Ureyen O, Namdaroglu OB, Kale MC, Emiroglu M, Yakan S, Ilhan E, Oztop MB, Kose S (2025) Antibiotic stewardship program (ASP) implementation is more effective than the national action plan for rational drug use. J Infect Dev Ctries 19:890–895. doi: 10.3855/jidc.20245

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Issue

Vol. 19 No. 06: June 2025

Section

Original Articles

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