Antimicrobial activity of Brachidontes variabilis extracts against multidrug-resistant bacteria clinically isolated
DOI:
https://doi.org/10.3855/jidc.21485Keywords:
Molluscs, Brachidontes variabilis, antimicrobial, antifungalAbstract
Introduction: Resistance to pathogens against kinds of traditional medicines is a public health problem, which calls for the continuous search for new compounds that are effective in eliminating diseases caused by these pathogens. Marine Animals come on top of animals that contain natural treasures of active substances that have not yet been discovered.
Methodology: In this study, two organic extracts (methanol and ethyl acetate) were prepared from the soft tissue of a marine organism (Brachidontes variabilis). Then, the antioxidant activity and phenol content were determined in these two extracts. Finally, their biological activities were studied toward drug-resistant microbes isolated from Syrian hospitals.
Results: The results showed that the IC50, the concentration required to reduce DPPH radicals by 50%, for methanol and ethyl acetate extracts were 179.286 and 73.676 mg/mL, respectively. The total phenolic contents of the methanol and ethyl acetate extracts were found to be 1.84 mg/g and 1.7 mg/g of the Gallic acid equivalent, respectively. The two extracts had an inhibitory effect on the growth of the following resistant bacterial species isolates: Staphylococcus aureus, Klebsiella pneumonia, Escherichia coli, and Pseudomonas aeruginosa, at a concentration of 5 mg/mL, with inhibitory zones ranging from 5 mm to 20 mm. The ethyl acetate extract has an inhibitory effect on the growth of the fungal pathogen Aspergillus fumigatus, which is resistant to fungal antibiotics.
Conclusions: The results of this study are promising in finding new compounds with antimicrobial effects against resistant pathogens.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Alissar Hussain, Basem Battah, Chadi Soukkarieh, Abdulaziz Saleh Alkhoshaiban, Yaman Walid Kassab, Badr Al-Ali
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
